发明名称 |
Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation |
摘要 |
A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1).
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申请公布号 |
US2013211145(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201113811305 |
申请日期 |
2011.07.22 |
申请人 |
MCGOWAN GRAHAM;GORIN BORIS;GOODBRAND BRUCE;BEJAN ELENA;ALPHORA RESEARCH INC. |
发明人 |
MCGOWAN GRAHAM;GORIN BORIS;GOODBRAND BRUCE;BEJAN ELENA |
分类号 |
C07C45/61 |
主分类号 |
C07C45/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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