发明名称 |
PROCESS FOR PREPARING TIOTROPIUM BROMIDE |
摘要 |
The present invention relates to a novel process for the preparation of tiotropium bromide there is provided a process for preparing tiotropium bromide comprising (i) reacting scopine oxalate with diethylamine in an inert solvent to form scopine; (ii) reacting scopine and methyl di-(2-dithienyl)glycoIate (MDTG) in the presence of an inorganic base, and in an inert solvent to form N-demethyltiotropium; (iii) reacting N-demethyltiotropium with bromomethane in an inert solvent to form tiotropium bromide; (iv) crystallizing tiotropium bromide in a mixture of methanol and acetone, and optionally thereafter, (v) micronizing the tiotropium bromide so formed. |
申请公布号 |
CA2863772(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
CA20132863772 |
申请日期 |
2013.02.08 |
申请人 |
HOVIONE INTERNATIONAL LTD |
发明人 |
SOBRAL, LUIS;TEMTEM MARCIO;ANTUNES, RAFAEL;NUNES, BRUNA |
分类号 |
C07D451/10 |
主分类号 |
C07D451/10 |
代理机构 |
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代理人 |
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主权项 |
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