发明名称 |
INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS |
摘要 |
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with a target molecule or substance (e.g., for use in new compound or drug discovery) are described. In some embodiments the device comprises comprises: (a) a spatially addressable array, said array comprising a plurality of separate and discrete locations thereon; (b) a plurality of different oligomers operably connected to said spatially addressable array at different ones of said separate and discrete locations; (c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and (d) a candidate chemical operably connected to each of said tag sequences, wherein each of said discrete locations is a unique identifier for its corresponding oligomer; and wherein said tag sequence is a unique identifier for its connected candidate chemical. |
申请公布号 |
WO2013096777(A3) |
申请公布日期 |
2013.08.15 |
申请号 |
WO2012US71258 |
申请日期 |
2012.12.21 |
申请人 |
WAKE FOREST UNIVERSITY HEALTH SCIENCES;NANOMEDICA LLC |
发明人 |
BONIN, KEITH;MACOSKO, JED C.;GAGLIANO, JASON;GUTHOLD, MARTIN;CUBICCIOTTI, ROGER |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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