发明名称 |
COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H3N2, H2N2, AND B INFLUENZA VIRUSES |
摘要 |
<p>Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H3N2, H2N2 and B influenza isolates. Provided herein are optimized H3N2, H2N2 and B influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.</p> |
申请公布号 |
CA2863981(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
CA20132863981 |
申请日期 |
2013.02.06 |
申请人 |
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
ROSS, TED M.;CARTER, DONALD M.;CREVAR, COREY J. |
分类号 |
C07K14/11;A61K39/145;A61P31/16;C12N15/44 |
主分类号 |
C07K14/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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