发明名称 |
Anti-TACE antibody molecules and their uses |
摘要 |
<p>Anti-TACE (ADAM17) antibodies are disclosed that for the first time in the art are capable of binding to TACE, of acting as antagonists of one or more its biological activities, in particular by binding to TACE in a cross domain binding mode in which residues in both the catalytic domain and in the cysteine rich/disintegrin domains (Dis-Cys) are involved in antibody binding to TACE, helping to improve the specificity of the antibody binding and/or helping to improve inhibition of TACE biological activity. The therapeutic uses of the antibodies, in particular for the treatment of cancer are disclosed.</p> |
申请公布号 |
AU2012213240(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
AU20120213240 |
申请日期 |
2012.01.30 |
申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
MURPHY, GILLIAN;TAPE, CHRISTOPHER;MCCAFFERTY, JOHN |
分类号 |
C07K16/00;A61K39/395;A61P35/00;C07K16/28;C07K16/40 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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