发明名称 |
Modified soluble FGF receptor Fc fusions with improved biological activity |
摘要 |
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules. |
申请公布号 |
AU2007326985(B2) |
申请公布日期 |
2013.08.15 |
申请号 |
AU20070326985 |
申请日期 |
2007.11.28 |
申请人 |
AVENTIS PHARMA S.A. |
发明人 |
SORDELLO, SYLVIE;NESBIT, MARK;CAMERON, BEATRICE;TROMBE, MARC;NICOLAZZI, CELINE;BLANCHE, FRANCIS |
分类号 |
C07K14/15;A61K38/17;A61K47/48;A61P35/00;C07K14/47;C07K14/71;C12N15/62 |
主分类号 |
C07K14/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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