发明名称 |
METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES AND METHODS OF MANUFACTURE AND USE THEREOF |
摘要 |
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide ("AMP") and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms.
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申请公布号 |
US2013210705(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201313745359 |
申请日期 |
2013.01.18 |
申请人 |
METALLOPHARM LLC;METALLOPHARM LLC |
发明人 |
COWAN JAMES A.;COWAN ADA S. |
分类号 |
C07D501/28;C07D401/10;C07D499/68;C07H17/04;C07K19/00 |
主分类号 |
C07D501/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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