Process for the preparation of esomeprazole magnesium dihydrate

摘要

A process for preparing Form A of (S) -5-methoxy-2- [ [ (4-methoxy-3, 5-dimethyl-2-pyridinyl) - methyl] sulf inyl] -1 H-benzimidazole magnesium dihydrate, processes for preparing various intermediates useful in the preparation of Form A of (S) -5-methoxy-2- [ [ (4-methoxy-3, 5-dimethyl-2-pyridinyl) -methyl] sulf inyl] -1 H-benzimidazole magnesium dihydrate and a novel polymorphic Form II of 5-methoxy-2- [ [ (4-methoxy-3, 5-dimethyl-2-pyridinyl) -methyl] thio] -1 H-benzimidazole