发明名称 |
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
摘要 |
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. |
申请公布号 |
AU2010266205(B2) |
申请公布日期 |
2013.08.15 |
申请号 |
AU20100266205 |
申请日期 |
2010.07.01 |
申请人 |
KEMPHARM, INC. |
发明人 |
MICKLE, TRAVIS;GUENTHER, SVEN;MICKLE, CHRISTAL;CHI, GUOCHEN;KANSKI, JAROSLAW;MARTIN, ANDREA K.;BERA, BINDU |
分类号 |
A01N43/42;A61K31/44 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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