The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.
申请公布号
CA2861124(A1)
申请公布日期
2013.08.15
申请号
CA20132861124
申请日期
2013.02.08
申请人
GENENTECH, INC.
发明人
WRANIK, BERND;EATON, DAN L.;CHRISTENSEN, ERIN H.;WU, JIANSHENG