发明名称 ANTIBODIES TO MUC16 AND METHODS OF USE THEREOF
摘要 The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.
申请公布号 EP2552959(A4) 申请公布日期 2013.08.14
申请号 EP20110760326 申请日期 2011.03.25
申请人 MEMORIAL SLOAN-KETTERING CANCER CENTER 发明人 SPRIGGS, DAVID;THAPI, DHARMARAO
分类号 C07K16/18;A61K39/395;A61P35/00;C07K16/30;C12N5/18;C12N15/13 主分类号 C07K16/18
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