发明名称 |
TRIAZOLE DERIVATIVE OR SALT THEREOF |
摘要 |
A triazole compound represented by the formula (I) or a salt thereof: (see formula I) wherein R1: -N(C1-6 alkyl)2 or -X-R4; R4: optionally substituted phenyl; X: -O-, -N(R0)-, -N(R0)S(O)2- or -N(R0)C(O)-; R0: the same or different from each other, -H or C1-6 alkyl; R2: -C1-6 alkyl or cycloalkyl; R3: optionally substituted phenyl; A and B: the same or different from each other, C1-6 alkyl. The triazole compound has a potent 11.beta.-HSD1 inhibitory activity, exhibits an excellent hypoglycerin effect which makes it usable in treating diabetes and insulin resistance.
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申请公布号 |
CA2580409(C) |
申请公布日期 |
2013.08.13 |
申请号 |
CA20052580409 |
申请日期 |
2005.09.14 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
MURAKAMI, TAKESHI;KAWANO, TOMOAKI;SHIRAKI, RYOTA;ISHII, HIROFUMI;YOSHIMURA, SEIJI;OHKAWA, TAKEHIKO;HOSAKA, MITSURU;FUKUDOME, HIROKI;INOKI, YUTAKA |
分类号 |
C07D249/08;A61K31/4196;A61K31/4439;A61K31/454;A61K31/55;A61P3/04;A61P3/06;A61P3/10;A61P9/12;A61P19/10;A61P25/28;A61P27/06;A61P43/00;C07D401/08;C07D403/08;C07D409/08;C07D487/04 |
主分类号 |
C07D249/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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