发明名称 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
摘要 Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
申请公布号 US8507477(B2) 申请公布日期 2013.08.13
申请号 US200913059164 申请日期 2009.08.14
申请人 WOOD MICHAEL R.;BELL IAN M.;KIM JUNE J.;SELNICK HAROLD G.;STUMP CRAIG A.;MERCK, SHARP & DOHME, CORP. 发明人 WOOD MICHAEL R.;BELL IAN M.;KIM JUNE J.;SELNICK HAROLD G.;STUMP CRAIG A.
分类号 C07D487/10;A61K31/55;A61P25/06 主分类号 C07D487/10
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