发明名称 |
Multimeric IL-15 soluble fusion molecules and methods of making and using same |
摘要 |
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Ralpha) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Ralpha domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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申请公布号 |
US8507222(B2) |
申请公布日期 |
2013.08.13 |
申请号 |
US201113238925 |
申请日期 |
2011.09.21 |
申请人 |
WONG HING C.;RHODE PETER;LIU BAI;ZHU XIAOYUN;HAN KAI-PING;ALTOR BIOSCIENCE CORPORATION |
发明人 |
WONG HING C.;RHODE PETER;LIU BAI;ZHU XIAOYUN;HAN KAI-PING |
分类号 |
C12N15/62;C07H21/04;C07K14/54;C07K14/71;C07K14/715;C12N5/00;C12N15/24;C12P21/00 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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