MUTANTS OF HUMAN CHONDROMODULIN-I (HCHM-I) AND USES THEREOF IN INHIBITING ANGIOGENESIS AND BONE RESORPTION

摘要

The invention provides a soluble polypeptide comprising an amino acid sequence represented by SEQ ID NO:9, or a soluble polypeptide comprising an amino acid sequence having at least 70% identity with an amino acid sequence represented by SEQ ID NO:9 and having an activity of inhibiting angiogenesis and/or an activity of inhibiting bone resorption. Such polypeptides inhibit angiogenesis and osteoclastogenesis and are therefore useful in the treatment of tendinitis, rheumatoid arthritis, arthritis deformans and malignant tumors. The invention further provides a nucleotide encoding the polypeptide, a process for preparing the polypeptide and a pharmaceutical composition comprising it.