Novel inden derivatives substituted with alkyl group containing pyridine, pharmaceutically acceptable salts or isomer thereof, process for the preparation thereof and pharmaceutical composition for prevention or treatment of PAR-1 related diseases containing the same as an active ingredient

摘要

PURPOSE: A pharmaceutical composition containing an alkyl-substituted indene derivative containing novel pyridine, or pharmaceutically acceptable salts or isomers thereof is provided to prevent or treat PAR-1 related diseases, inflammation, or cancer. CONSTITUTION: An alkyl-substituted indene derivative containing pyridine is denoted by chemical formula 1. A pharmaceutical composition for preventing or treating PAR-1 activation-related diseases contains the indene derivative, salts, or isomers as an active ingredient. A pharmaceutical composition for cardiovascular treatment aid is alternately used with cardiovascular drugs such as aspirin, clopidogrel, ticlopidine, abciximab, or tirofiban.