| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to molecular biology, genetics and medicine. What is presented is a lipid modified double-stranded RNA comprising an antisense chain having a nucleotide sequence complementary to a target sequence, and a sense chain having a nucleotide sequence complementary to the antisense chain. The sense chain comprises a lipid attached either directly or via a linker to at least one of the first six nucleotides of the 5'-terminal end. The given double-stranded RNA can inhibit expression of the target gene. The presented RNA possesses highly nuclease resistance, intracellular accumulation effectiveness and a high effect of RNA interference.EFFECT: invention may be used in medicine for treating the diseases mediated by genetic disorders.12 cl, 10 dwg, 2 ex |
