| 摘要 |
FIELD: biotechnologies.SUBSTANCE: invention relates to new derivatives of 4-aminopyrimidine, having antagonistic activity in respect to the receptor H. In the formula: Ris selected from Calkyl, Ccycloalkyl-Calkyl, aryl-Calkyl, the group of the formulaRand Rtogether with the atom N, with which they are linked, creating the saturated heterocyclic group, which may be a 4-7-member monocyclic or 9-member condensed bycyclic one, where the specified heterocyclic group may contain up to two atoms N and does not contain any other heteroatoms, and may be unnecessarily substituted with one or more substitutes, independently selected from Calkyl and NRR, provided that if the heterocyclic group either contains 2 atoms N and is not substituted with the group NRR, or comprises 1 atom N and is substituted with one group NRR; or Ris H, and Ris pyrrolidinyl substituted with Calkyl group; where Ris H or Calkyl; Ris H or Calkyl; Rand Ris H; Ris aryl group; n is equal to 1; and aryl is phenyl group, unnecessarily substituted with halogen. The invention also relates to a pharmaceutical composition containing the specified compounds, to application of compounds for production of a medicinal agent for treatment of such diseases as an allergic, immunological or inflammatory diseases or pain, and also to a method for production of the specified compounds.EFFECT: higher efficiency of application of compounds in treatment of diseases.34 cl, 30 ex |
