| 摘要 |
FIELD: medicine.SUBSTANCE: invention refers to medicine, and concerns a combined pharmaceutical composition for treating skin diseases. The composition contains betamethasone, preferentially betamethasone dipropionate, urea and at least one adjuvant. As adjuvants, the composition contains a hydrophobic component, an emulsifier, a preserving agent, a buffer agent, a non-aqueous solvent and water. A method for preparing the declared composition consists in the fact that the melted hydrophobic component, emulsifier and water are emulsified, and then betamethasone and the preserving agent are introduced at temperature below 60°C, homogenised and added with a prepared solution of urea and the buffer agent.EFFECT: pharmaceutical composition is characterised by high pharmacological activity, stability, uniform distribution of the active ingredients.7 cl, 8 ex, 1 tbl |
