| 摘要 |
FIELD: biotechnologies.SUBSTANCE: invention relates to derivatives of [1-(benzyl)piperydine-4-yl]-([1,3,4]thiadiazole- 2-yl)amine and [1-(benzyl)piperydine-4-yl]-(thiazole-2-yl)amine of the formula (I) or their pharmaceutically acceptable salts, or their pharmaceutically acceptable salts, where R means hydrogen; Rmeans phenyl, substituted with 1, 2 or 3 substitutes, each of them is independently selected from a group containing halogen, cyano, Calkyl, perfluoroCalkyl and perfluoroCalkoxy; Rmeans hydrogen or Calkyl; Rmeans hydrogen, trifluoromethyl or cyano; X means N or CR, where Ris trifluoromethyl. Also the invention relates to a pharmaceutical composition containing compounds of the formulaas an active ingredient. The following derivatives are presented: derivatives of [1-(benzyl)piperydine-4-yl]-([1,3,4]thiadiazole-2-yl)amine and [1-(benzyl)piperydine-4-yl]-(thiazole-2-yl)amine of the formula (I) representing quick-dissociating antagonists of dopamine 2 receptors and used as medicinal agents for treatment or prevention of central nervous system.EFFECT: improved properties of compounds.7 cl, 22 ex |
