发明名称 |
ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES |
摘要 |
The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides. |
申请公布号 |
WO2013115926(A2) |
申请公布日期 |
2013.08.08 |
申请号 |
WO2012US71762 |
申请日期 |
2012.12.27 |
申请人 |
ATYR PHARMA, INC. |
发明人 |
BUECHLER, YING JI;WU, CHI-FANG;ADAMS, RYAN A.;WATKINS, JEFFRY D.;MENDLEIN, JOHN D. |
分类号 |
C07K19/00;A61K38/16;A61P35/00;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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