NON-AQUEOUS LIQUID COMPOSITION

摘要

A drug-dissolved non-aqueous liquid composition comprising a drug, dioleylphosphatidylcholine, tocopherol and an organic solvent, wherein the ratio of the blend concentration of dioleylphosphatidylcholine to that of tocopherol falls within the range from 75/25 to 25/75, the blend concentration of dioleylphosphatidylcholine falls within the range from 15 to 85% (w/w) and the blend concentration of tocopherol falls within the range from 15 to 85% (w/w). The phase of the non-aqueous liquid composition can be changed into a non-lamellar liquid crystal upon the contact with water, a phosphate buffer, a body fluid, a tear fluid or a vitreous fluid.