发明名称 |
COMBINATION OF A RTK INHIBITOR WITH AN ANTI - ESTROGEN AND USE THEREOF FOR THE TREATMENT OF CANCER |
摘要 |
A pharmaceutical combination comprising (a) a RTK inhibitor selected from the group consisting of compounds of Formula I or a tautomer thereof, compounds of Formula II or a tautomer thereof, compounds of Formula III or a tautomer thereof, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt of the tautomer, or a mixture thereof; and (b) one or more anti-estrogen compounds, or a pharmaceutically acceptable salt thereof; such as tamoxifen, toremifene, fulvestrant, raloxifene or raloxifene hydrochloride; the uses of such combination in the treatment or prevention of proliferative diseases; and methods of treating a subject suffering from a proliferative disease; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination. |
申请公布号 |
WO2013116293(A1) |
申请公布日期 |
2013.08.08 |
申请号 |
WO2013US23781 |
申请日期 |
2013.01.30 |
申请人 |
NOVARTIS AG;YOVINE, ALEJANDRO;SQUIRES, MATTHEW;REDDICK, CATHERINE;ZHANG, YONG |
发明人 |
YOVINE, ALEJANDRO;SQUIRES, MATTHEW;REDDICK, CATHERINE;ZHANG, YONG |
分类号 |
A61K31/138;A61K31/4535;A61K31/4709;A61K31/496;A61K31/5377;A61K31/56;A61K45/06;A61P35/00 |
主分类号 |
A61K31/138 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|