NOVEL METHOD FOR PRODUCING METABOLITES FROM OMEPRAZOLE USING BACTERIAL CYTOCHROME P450, AND COMPOSITION FOR SAME

摘要

The present invention relates to a novel method for producing metabolites from omeprazole using bacterial cytochrome P450 and to a composition for same, and more specifically, to a composition and a kit for producing a 5'-hydroxyl product from omeprazole, the composition and kit containing bacterial cytochrome P450 BM3(CYP102A1) or a mutant thereof, and to a method for producing same. The composition, the kit, and the production method are economical while enabling highly efficient mass production of the 5'-hydroxyl product from the omeprazole, and thus will significantly contribute to the development of a novel drug using the metabolites from the omeprazole.