IMINE DERIVATIVE CONTAINING OPTICALLY ACTIVITY TRIFLUOROMETHYL GROUP, METHOD OF MANUFACTURING THE SAME, AND METHOD OF MANUFACTURING OPTICAL ACTIVITY AMINE DERIVATIVE CONTAINING TRIFLUOROMETHYL GROUP USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide: an imine derivative containing an optical activity trifluoromethyl group that is useful as a synthetic intermediate of a medicine and pesticide; a method of manufacturing the same; and a method of manufacturing a cyclic amine derivative using the same.SOLUTION: A novel imine containing an optical activity trifluoromethyl group of a compound of formula (1) is obtained by reacting aldehyde containing a trifluoromethyl group or the hydrate with optical activity 2-ethoxy-1-phenylethylamine, and is made to react with allyl halides to obtain an optical activity fluorine-containing amine derivative.