发明名称 |
ANTI-VEGF ANTIBODIES AND USES THEREOF |
摘要 |
Provided are monoclonal antibodies and antigen binding fragments thereof that specifically bind vascular endothelial growth factor (VEGF). The anti-VEGF monoclonal antibodies block VEGF binding to its receptors (e.g., VEGFR1 and/or VEGFR2) and prevent phosphorylation of VEGFR2 by VEGF. Also provided are methods of using the monoclonal anti-VEGF antibodies for treatment of disease, including cancer.
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申请公布号 |
US2013202615(A1) |
申请公布日期 |
2013.08.08 |
申请号 |
US201113703947 |
申请日期 |
2011.06.14 |
申请人 |
CROY LESLIE A.;PARIS MARK J.;SMITH ERNEST S.;VACCINEX, INC. |
发明人 |
CROY LESLIE A.;PARIS MARK J.;SMITH ERNEST S. |
分类号 |
C07K16/22;A61K39/395;A61K45/06;A61K47/48;A61N5/10;G01N33/74 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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