METHODS FOR PROMOTING NEURON SURVIVAL, AXONAL GROWTH AND/OR REGENERATION

摘要

Methods of stimulating neuron survival, axon growth and/or promoting axon regeneration of a neogenin expressing cell in a subject in need thereof are provided. The methods involve for example, administering to a subject in need thereof a PPC inhibitor, optionally a SKI-1 inhibitor and/or a furin inhibitor. Cleaved RGMa inhibits neogenin mediated axon growth. The SKI-1 inhibitor and/or furin inhibitor inhibit cleavage of RGMa, thereby stimulating neuron survival, axon growth and/or promoting axon regeneration.