发明名称 |
PROMOTERS FOR INCREASED PROTEIN EXPRESSION IN MENINGOCOCCUS |
摘要 |
New promoters are described to drive transcription in meningococcus e.g. for over-expression of protein antigens for retention in membrane vesicles. Modified porA promoters lack the wild-type poly-G sequence which can cause phase variation. Meningococcal rRNA-coding genes (e.g. for 16S rRNA) can be used to drive transcription of a protein-coding gene. These approaches can be used in combination. |
申请公布号 |
WO2013113917(A1) |
申请公布日期 |
2013.08.08 |
申请号 |
WO2013EP52108 |
申请日期 |
2013.02.01 |
申请人 |
NOVARTIS AG |
发明人 |
DELANY, ISABEL;GUADAGNUOLO, SERAFINA |
分类号 |
C12N15/74;C12N15/63 |
主分类号 |
C12N15/74 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|