| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicament for treatment of the damaging effect of stroke or other injury to the CNS exacerbated by fever or hyperglycemia.SOLUTION: Peptides and peptidomimetics inhibit interaction between domain 2 of postsynaptic density-95 protein (PSD-95 d2) containing a PDZ domain and the C-terminus of NR2B subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) containing a PL motif. Two particularly preferred peptides are KLSSIESDV (SEQ ID NO.: 9), and KLSSIETDV (SEQ ID NO.: 10). |
