发明名称 |
Immunoregulator Compounds |
摘要 |
The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1 P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically Mycobacterium tuberculosis. Such compounds are characterised in that they stimulate macrophagic Phospholipase D (PLD) (FIG. 1). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides.
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申请公布号 |
US2013202648(A1) |
申请公布日期 |
2013.08.08 |
申请号 |
US201313743516 |
申请日期 |
2013.01.17 |
申请人 |
"TOR VERGATA" UNIVERSITA DEGLI STUDI DI ROMA;UNIVERSITA DEGLI STUDI DI ROMA "TOR VERGATA" |
发明人 |
FRAZIANO MAURIZIO;GARG SANJAY KUMAR;CIARAMELLA ANTONIO;AURICCHIO GIOVANNI;VOLPE ELISABETTA;MARTINO ANGELO;BALDINI PATRIZIA MORENA;DE VITO PAOLO;GALATI DOMENICO;COLIZZI VITTORIO |
分类号 |
A61K31/661;A61K31/047;A61K31/132 |
主分类号 |
A61K31/661 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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