发明名称 |
NUCLEIC ACID MOLECULES ENCODING RANTES, AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME |
摘要 |
Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the nucleotide sequence encoding RANTES and fragments and variants thereof in combination with nucleic acid sequences encoding immunogens are provided. Recombinant viral vectors comprising the nucleotide sequence encoding RANTES and fragments and variants thereof with or without a nucleic acid sequence encoding immunogens are also provided as are live attenuated pathogens comprising a nucleotide sequence encoding RANTES and fragments and variants thereof. Methods of modulating immune responses and of inducing an immune response against an immunogen are also disclosed. |
申请公布号 |
EP2539354(A4) |
申请公布日期 |
2013.08.07 |
申请号 |
EP20110740539 |
申请日期 |
2011.02.08 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WEINER, DAVID, B.;BOYER, JEAN, D.;KUTZLER, MICHELE |
分类号 |
A61K39/21 |
主分类号 |
A61K39/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|