发明名称 |
CROSS-SPECIES-SPECIFIC PSMAXCD3 BISPECIFIC SINGLE CHAIN ANTIBODY |
摘要 |
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule. |
申请公布号 |
KR20130088013(A) |
申请公布日期 |
2013.08.07 |
申请号 |
KR20127028639 |
申请日期 |
2011.04.01 |
申请人 |
AMGEN RESEARCH (MUNICH) GMBH |
发明人 |
KUFER PETER;RAUM TOBIAS;KISCHEL ROMAN;LUTTERBUESE RALF;HOFFMANN PATRICK;RAU DORIS;MANGOLD SUSANNE;KLINGER MATTHIAS;SCHALLER EVELYNE;HAUSMANN SUSANNE;FLUHR PETRA;STEIGER CAROLA |
分类号 |
C07K16/28;A61K39/395;C07K16/30;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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