发明名称 |
BIS(THIO-HYDRAZIDE AMIDE) SALTS FOR TREATMENT OF CANCERS |
摘要 |
<p>Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ 2 M + or M 2+
Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R 1 -R 4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R 1 and R 3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R 2 and R 4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is -O or -S. M + is a pharmaceutically acceptable monovalent cation and M 2+ is a pharmaceutically acceptable divalent cation. Also disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt.</p> |
申请公布号 |
EP1781604(B1) |
申请公布日期 |
2013.08.07 |
申请号 |
EP20050762347 |
申请日期 |
2005.06.20 |
申请人 |
SYNTA PHARMACEUTICALS CORP. |
发明人 |
KOSTIK, ELENA;VAGHEFI, FARID;LIANG, GUIQING;KOYA, KEIZO;SUN, LIJUN;TATSUTA, NORIAKI;CHEN, SHOUJUN;INOUE, TAKAYO;XIA, ZHI-QIANG |
分类号 |
C07C327/56;A61K31/16;A61P35/00 |
主分类号 |
C07C327/56 |
代理机构 |
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代理人 |
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主权项 |
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