发明名称 Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate and its purification for use as pharmaceutically active compound
摘要 The present invention relates to processes for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate, i.e. the compound of the formula (I) and to a process for purifying the crude product of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphinyldimethane (1:2) of the formula (II) is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
申请公布号 US8501945(B2) 申请公布日期 2013.08.06
申请号 US20100955864 申请日期 2010.11.29
申请人 MAIS FRANZ-JOSEF;REHSE JOACHIM;JOENTGEN WINFRIED;SIEGEL KONRAD;BAYER INTELLECTUAL PROPERTY GMBH 发明人 MAIS FRANZ-JOSEF;REHSE JOACHIM;JOENTGEN WINFRIED;SIEGEL KONRAD
分类号 C07D403/04;A61K31/506;A61P19/02 主分类号 C07D403/04
代理机构 代理人
主权项
地址