发明名称 |
Identification of TSH receptor autoantibodies using affinity-purified antibodies |
摘要 |
The present invention relates to the use of affinity-purified polyclonal human autoantibodies against the TSH receptor (TSHR-Auto-Ab), obtained from the serum of Graves' disease patients and which have been purified to obtain biochemical homogeneity and comprise a specific activity of at least 1 IU/mg protein (human immunoglobulin). Also disclosed is the use of animal antibodies, which compete with the former for the binding sites of a functional human TSH receptor, as a specific binding reagent in an immunological determination method for the clinical identification of autoantibodies against the TSH receptor (TSHR-Auto-Ab) in a sample of a biological fluid of a patient to be examined for Graves' disease.
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申请公布号 |
US8501415(B2) |
申请公布日期 |
2013.08.06 |
申请号 |
US20030536577 |
申请日期 |
2003.10.31 |
申请人 |
BERGMANN ANDREAS;COSTAGLIOLA SABINE;VASSART GILBERT;B.R.A.H.M.S. GMBH |
发明人 |
BERGMANN ANDREAS;COSTAGLIOLA SABINE;VASSART GILBERT |
分类号 |
G01N33/53;C07K16/28;G01N33/564;G01N33/566;G01N33/76 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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