发明名称 |
Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle |
摘要 |
A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter.
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申请公布号 |
US8501204(B2) |
申请公布日期 |
2013.08.06 |
申请号 |
US20090993954 |
申请日期 |
2009.05.21 |
申请人 |
ICHIKAWA SOSAKU;KUROIWA TAKASHI;UNIVERSITY OF TSUKUBA |
发明人 |
ICHIKAWA SOSAKU;KUROIWA TAKASHI |
分类号 |
A61K8/02 |
主分类号 |
A61K8/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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