| 发明名称 |
Production of glycoproteins with reduced O-glycosylation |
| 摘要 |
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more alpha-1,2-mannosidases.
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| 申请公布号 |
US8501438(B2) |
申请公布日期 |
2013.08.06 |
| 申请号 |
US201213484665 |
申请日期 |
2012.05.31 |
| 申请人 |
BOBROWICZ PIOTR;COOK W. JAMES;KETT WARREN;GLYCOFI, INC. |
发明人 |
BOBROWICZ PIOTR;COOK W. JAMES;KETT WARREN |
| 分类号 |
C12P21/06;A01N43/78;C07D277/26;C12N1/15;C12N1/19 |
主分类号 |
C12P21/06 |
| 代理机构 |
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代理人 |
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| 地址 |
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