| 发明名称 |
Method for the production of a single heavy chain antibody |
| 摘要 |
The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
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| 申请公布号 |
US8502014(B2) |
申请公布日期 |
2013.08.06 |
| 申请号 |
US20100833132 |
申请日期 |
2010.07.09 |
| 申请人 |
GROSVELD FRANK;ERASMUS UNIVERSITEIT ROTTERDAM |
发明人 |
GROSVELD FRANK |
| 分类号 |
A01K67/027;C12P21/00;A61K39/395;A61P1/04;A61P3/10;A61P19/02;A61P21/04;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/00;A61P37/02;A61P37/08;C07K16/00;C07K16/18;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;C12R1/91 |
主分类号 |
A01K67/027 |
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