发明名称 |
QUINOXALINYL MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS |
摘要 |
The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. |
申请公布号 |
CA2654945(C) |
申请公布日期 |
2013.08.06 |
申请号 |
CA20072654945 |
申请日期 |
2007.06.26 |
申请人 |
ENANTA PHARMACEUTICALS, INC. |
发明人 |
OR, YAT, SUN;MOORE, JOEL D.;LIU, DONG;SUN, YING;GAI, YONGHUA;TANG, DATONG;NIU, DEQIANG;XU, GUOYOU;WANG, ZHE |
分类号 |
C07D409/14;A61K31/495;A61P31/12;C07D401/14;C07D403/12;C07D413/14;C07D417/14;C07D471/04;C07D475/00;C07D487/04;C07D491/04;C07D495/04 |
主分类号 |
C07D409/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|