NOVEL METHOD FOR PREPARING 1-OXACEPHALOSPORIN DERIVATIVES

摘要

PURPOSE: A novel method for preparing oxacephalosporin derivatives is provided to enable quantitative addition of a halogenating agent, thereby reducing a production cost and enhancing yield with excellent stability. CONSTITUTION: A method for preparing oxacephalosporin derivatives of chemical formula 1 comprises the steps of reacting a compound of chemical formula 2 with a halogenating agent under the presence of a base; and adding a compound of chemical formula 3 and a reducing agent. The halogenating agent is selected among trichloroisocyanuric acid, N-iodosuccinimide, N-bromosuccinic imide, N-chlorosuccinimide, N-fluorosuccinimide, and a mixture thereof. The halogenating agent is used in a quantity of 1-5 moles per 1 mole of the compound of chemical formula 2.