POLYNUCLEOTIDE ENCODING ANTIGENIC HIV TYPE B POLYPEPTIDE, THE POLYPEPTIDE, AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide polynucleotides encoding new immunogenic HIV polypeptides.SOLUTION: The present invention relates to polynucleotides encoding new immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof. In certain embodiments, the present invention relates to synthetic polynucleotides and/or expression cassettes encoding HIV polypeptides.