发明名称 |
Methods of reducing immunogenicity against Factor VIII in individuals undergoing Factor Vlll therapy |
摘要 |
The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain. -156- |
申请公布号 |
AU2013204237(A1) |
申请公布日期 |
2013.08.01 |
申请号 |
AU20130204237 |
申请日期 |
2013.01.12 |
申请人 |
PUGET SOUND BLOOD CENTER;BIOGEN IDEC MA INC. |
发明人 |
JIAMG, HAIYAN;LIU, TONGYAO;KRISHNAMOORTHY, SRIRAM;JOSEPHSON, NEIL;PIERCE, GLENN |
分类号 |
C12N15/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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