发明名称 |
Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside |
摘要 |
A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside. |
申请公布号 |
AU2008321225(B2) |
申请公布日期 |
2013.08.01 |
申请号 |
AU20080321225 |
申请日期 |
2008.11.06 |
申请人 |
PHOENIX BIOTECHNOLOGY INC. |
发明人 |
YANG, PEIYING;NEWMAN, ROBERT A.;ADDINGTON, CRANDELL O. |
分类号 |
A61K31/704;A61K31/58;G01N33/574 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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