发明名称 |
Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods |
摘要 |
The present invention relates generally to methods of in vitro diagnostics, in particular the use of a compound selected from the group consisting of fibroblast growth factor 23 (FGF23), inorganic phosphorus (P), the product of inorganic phosphorus and total calcium (P x tCa), osteopontin (OPN) and parathyroid hormone (PTH) as biomarker. Said biomarkers can be used to monitor the modulation of fibroblast growth factor receptor (FGFR) kinase activity, in particular its inhibition, and/or the occurrence of secondary effects of FGFR inhibition. The invention further provides methods and kits relating to these uses. |
申请公布号 |
AU2013206768(A1) |
申请公布日期 |
2013.08.01 |
申请号 |
AU20130206768 |
申请日期 |
2013.07.10 |
申请人 |
NOVARTIS AG |
发明人 |
GRAUS PORTA, DIANA;GUAGNANO, VITO;MARRER, ESTELLE;VERDES, PABLO |
分类号 |
G01N33/68;G01N33/74;G01N33/84 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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