PHENYL-[1,2,4]-OXADIAZOL-5-ONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

摘要

THE INVENTION RELATES TO PHENYL-[1,2,4]-OXADIAZOL-5-ONE DERIVATIVES WITH PHENYL GROUP IN ALL ITS STEREOISOMERIC FORMS AND MIXTURES IN ANY RATIO, AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS AND TAUTOMERIC FORMS SHOWING PPAR DELTA AGONIST ACTIVITY. WHAT IS DESCRIBED ARE COMPOUNDS OF THE FORMULA 1, WHEREIN THE RADICALS ARE AS DEFINED, AND THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS AND PROCESSES FOR THEIR PREPARATIONS. THE COMPOUNDS ARE SUITABLE FOR THE TREATMENT AND/OR PREVENTION OF DISORDERS OF FATTY ACID METABOLISM AND GLUCOSE UTILIZATION DISORDERS AS WELL AS OF DISORDERS IN WHICH INSULIN RESISTANCE IS INVOLVED AND DEMYELINATING AND OTHER NEURODEGENERATIVE DISORDERS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM.