发明名称 |
CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS |
摘要 |
<p>Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.</p> |
申请公布号 |
EP1951231(B1) |
申请公布日期 |
2013.07.31 |
申请号 |
EP20060836448 |
申请日期 |
2006.10.19 |
申请人 |
CALIFORNIA PACIFIC MEDICAL CENTER;CATHOLIC HEALTHCARE WEST, DOING BUSINESS AS ST. MARY'S MEDICAL CENTER |
发明人 |
YANG, LI-XI |
分类号 |
A61K31/44;A61K45/06;C07D491/22 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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