发明名称 N,N'-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
摘要 The invention is directed to a compound of Formula (I), wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C1-C4 alkyl group, nitro group, and -OCF3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.
申请公布号 US8497296(B2) 申请公布日期 2013.07.30
申请号 US201213423040 申请日期 2012.03.16
申请人 HASSAN TAREK ABOUL-FADL MOHAMED;KADI ADNAN AHMED;ABDEL-AZIZ HATEM ABDEL-KHADER;KING SAUD UNIVERSITY 发明人 HASSAN TAREK ABOUL-FADL MOHAMED;KADI ADNAN AHMED;ABDEL-AZIZ HATEM ABDEL-KHADER
分类号 A61K31/404;C07D403/12 主分类号 A61K31/404
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