发明名称 |
Medicinal compositions comprising buprenorphine and nalmefene |
摘要 |
An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount nalmefene such that the ratio by weight of buprenorphine to nalmefene delivered to or reaching the plasma of a patient is in the range 22.6:1 to 40:1. The analgesic action of the buprenorphine is potentiated by the low dose of nalmefene. Also provided are a method of treatment of pain and the use of nalmefene and buprenorphine for the manufacture of a medicament.
|
申请公布号 |
US8497280(B2) |
申请公布日期 |
2013.07.30 |
申请号 |
US20080529314 |
申请日期 |
2008.02.15 |
申请人 |
CHAPLEO CHRISTOPHER BOURNE;HYDE NEIL;RB PHARMACEUTICALS LIMITED |
发明人 |
CHAPLEO CHRISTOPHER BOURNE;HYDE NEIL |
分类号 |
A61K31/44 |
主分类号 |
A61K31/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|