发明名称 |
Anti-glypican-3 antibody having improved kinetics in plasma |
摘要 |
A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.
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申请公布号 |
US8497355(B2) |
申请公布日期 |
2013.07.30 |
申请号 |
US20080733933 |
申请日期 |
2008.09.26 |
申请人 |
IGAWA TOMOYUKI;KURAMOCHI TAICHI;SHIRAIWA HIROTAKE;TSUNODA HIROYUKI;TACHIBANA TATSUHIKO;ISHIGURO TAKAHIRO;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA TOMOYUKI;KURAMOCHI TAICHI;SHIRAIWA HIROTAKE;TSUNODA HIROYUKI;TACHIBANA TATSUHIKO;ISHIGURO TAKAHIRO |
分类号 |
C07K16/30;A61K39/395;C07H21/04;C12N15/13;C12P21/08 |
主分类号 |
C07K16/30 |
代理机构 |
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地址 |
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