NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS

摘要

In a compound I:Z is a group of the formula -C≡C-Ror -CH=CH-R; m and n is 0, 1 or 2; Y is a linking group or is absent; Ris H or halogen or C-Calkyl group; ---- is an optional double bond; and R, Rand Rare selected from a wide range of optionally substituted alkyl, cycloalkyl, aryl and heterocyclic groups. Compounds are mGlu5 antagonists useful for the treatment of neuromuscular dysfunction of the lower urinary tract, migraine and gastroesophagael reflux disease in mammals. Preferred compounds I are those having the formula